About EndoS

EndoS is a secreted enzyme from Streptococcus pyogenes that specifically hydrolyzes the functionally important glycan in IgG. EndoS has proven effective in a range of autoimmune models including rheumatoid arthritis (RA), immune thrombocytopenic purpura (ITP), autoimmune hemolysis, multiple sclerosis (MS) and autoimmune blistering skin disorder.

Given the importance of the IgG glycans in orchestrating the IgG’s effector functions and the unique specificity of EndoS for these glycans, we believe that En­doS has potential as a novel therapy for antibody-mediated autoim­mune diseases.