Bacteria from local infections such as urinary tract infection or pneumonia entering the blood stream in significant amounts can initiate a strong systemic immune reaction. This reaction is called severe sepsis and puts the patient in a life threatening state. Pathogenic bacteria in the bloodstream are known to activate a number of different inflammatory processes and cause clotting disturbances. Bacteria in the bloodstream can be satisfactory treated with antibiotics, but the inflammatory reaction to the bacteria can put the patient into a life threatening state characterized by significantly decreased blood pressure, high respiratory rate and elevated heart rate. These clinical manifestations put the patient in immediate danger of multiple organ failure and fatality.
HBP-assay provide clinicians at Emergency Departments with early signals of impending severe sepsis enabling treatment with antibiotics and fluid resuscitation to be initiated much earlier, potentially saving thousand of lives.
Severe sepsis is an expensive international problem, both in terms of casualties and treatment of hundreds of thousands of cases each year. In the EU, costs relating to treatment of sepsis mount to an estimated €7.6 billion annually.